Turns out my Dell monitor was the culprit. It has a built-in USB hub that was apparently interfering with low-level system stuff in my OptiPlex. The hub worked fine for awhile and then something in it flaked out...
I guess for the $400 bucks I paid for it didn't really cover the USB hub! It works good for simple stuff like my thumbdrive and camera but no good for serious duty.
Cheers!
Damien
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