I should also add, some Desktop Environments provide an easier way to configure the mouse.. so there may be able to handle the transition a bit better, I don't use one personally.
One thing you may notice is the mouse cursors direction, it'll probably be pointing the wrong way..
The following was gleaned from the fluxbox startup script:
% xsetroot -cursor_name right_ptr
Note, this doesn't appear to effect GTK applications like Firefox.. as a right handed person I haven't had to deal with any of this before, but I'll keep looking into a solution for you. (and the archives..).
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