You don't want to run RAID0, period, unless you have a super-stringent, continuously running, backup setup. If any 1 disk in a RAID0 array dies, you lose all data in the array.
The only time you should use RAID0 is when it's part of a RAID1+RAID0 (aka RAID1+0, or RAID10). But, that requires 4 drives as a minimum.
You also don't want to create RAID arrays using different sized or different speed of drives. It's possible to do, but will impact throughput for any data stored on the slower drives/interfaces.
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