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The 8 series is for eight physical CPUs on a board -- that is probably way overkill for your applications, and you pay a heavy premium for it. The 2 series is for two physical CPUs, more akin to a traditional dual Xeon system. There is also a 4 series where obviously you can use four physical CPUs. Each of these can be single, dual or quad core.
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Right, I did some research on the newer Opteron CPUs and I see what you mean -- I may be able to get my hands on cheap 8000 series CPUs which is why I looked at those, From what I can see the 2000, 4000, and 8000 series are the same in all respects (performance, TDP, ect.) except the ability to support more CPU's. So two 8000 series CPUs can't hurt ...